Active Ingredient(s)	Pazopanib
Manufacturer	GlaxoSmithKline
Country of Origin	India
Reference	N/A

What is Votrient (Pazopanib) used for?

Votrient is used to treat renal cell carcinoma or soft tissue sarcoma in patients who have already been treated with chemotherapy. Votrient contains the active ingredient Pazopanib and is classified as a tyrosine kinase inhibitor.

How should I use Votrient (Pazopanib)?

Recommended dosages are as follows. These are guidelines only. Follow the instructions given to you by your doctor.

• Renal Cell Carcinoma (RCC):
  • Starting dosage: 800mg per day
  • Once a loading dose is reached: reduce dosage by 400mg
  • Further decreases or increases of 200mg until a suitable level is reached
• Soft Tissue Sarcoma (STS):
• Starting dosage: 800mg per day
• Further decreases or increases of 200mg until a suitable level is reached

Votrient tablets should be swallowed whole with a glass of water. Take the tablets on an empty stomach (at least one hour before or two hours after a meal).

Hepatic impairment may require different dosages from patients with healthy hepatic function.

What are the side effects of Votrient (Pazopanib)?

The most serious side effect of Votrient is hepatotoxicity, which can sometimes be fatal.

Signs of an allergic reaction including hives, difficult breathing, or swelling of the face, lips, tongue, or throat will require urgent medical attention.

Other serious side effects of Votrient include:

• slow healing of a wound or surgical incision;
• dizziness, fainting, fast or pounding heartbeat;
• fever, chills, easy bruising, flu symptoms, sores in your mouth and throat;
• feeling short of breath (even with mild exertion), swelling, rapid weight gain;
• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• nosebleed, bleeding gums;
• any wound that will not heal;
• nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• sudden numbness or weakness (especially on one side of the body), sudden severe headache, confusion, problems with vision, speech, or balance;
• seizures (convulsions);
• sudden cough, wheezing, rapid breathing, coughing up blood;
• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
• pain, swelling, warmth, or redness in one or both legs;
• dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

If you notice any of the above side effects, contact your doctor as soon as possible.

Less severe side effects you may notice can include:

• mild nausea or vomiting, diarrhea;
• weight loss;
• changes in hair or skin color;
• joint or muscle pain;
• tumor pain, mild headache;
• unusual or unpleasant taste in your mouth

Please Note

Regular blood tests are necessary when taking Votrient. Pazopanib has been linked with fatal hepatotoxicity.

It is not recommended that pregnant or breast-feeding women taken Votrient. There is a chance of Pazopanib harming the unborn baby and it is not known if Pazopanib is passed through breastmilk.

Votrient can interfere with wound healing. Tell your doctor if you are taking any blood thinners. If you require any form of surgery, make sure the doctors are aware that you are taking Votrient.