Active Ingredient(s)	Liposomal Amphotericin B
Manufacturer	Gilead
Country of Origin	Turkey
Reference	N/A

What is Ambisome (Liposomal Amphotericin B) used for?

AmBisome contains the active ingredient Liposomal Amphotericin B. This is a treatment of choice for several different fungal infections. It can be used to treat systemic fungal infections of Aspergillus species, Candida species, and/or Cryptococcus species, Cryptococcal meningitis and Visceral Leishmaniasis. Liposomal Amphotericin B is an antifungal antibiotic. It works by killing the fungus and stopping further spread of infection.

How should I use Ambisome (Liposomal Amphotericin B)?

AmBisome contains a vial of powder. This will need to be mixed in a solution suitable for administration via an intravenous drip prior to use. Your doctor will advise the ideal dosage for you.

What are the side effects of Ambisome (Liposomal Amphotericin B)?

AmBisome can cause a wide range of different side effects, some more common than others. Contact your doctor if any side effects become troublesome or persistant.

More commone side effcts:

• Hypokalemia
• Hypomagnesemia
• Chills
• Anemia
• Nephrotoxicity
• Nausea
• Vomiting
• Diarrhea
• Rash
• Dyspnea
• Hyperglycemia
• Insomnia
• Alkaline phosphatase increase
• Infusion reaction
• Headache
• Hypertension
• Abdominal pain
• Tachycardia
• Lung disorder
• Blood transfusion reaction
• Hypocalcemia
• Cough
• Bilirubinemia
• Leukopenia
• ALT increased
• Constipation
• Peripheral edema
• Pain
• Anorexia
• Anxiety
• Hypotension
• Sepsis
• AST increased
• Pleural effusion
• Confusion
• Thrombocytopenia
• Weakness
• Back pain
• Edema
• Hyponatremia
• Chest pain
• Hypervolemia
• Pruritus
• Rhinitis
• Phlebitis

Less common side effects:

• Abnormal thinking
• Acidosis
• Agitation
• Alopecia
• Arthralgia
• Asthma
• Bruising
• Cardiovascular abnormalities
• Coagulation disorder
• Cellulitis
• Depression
• Dizziness
• Electrolyte abnormalities
• Fluid overload
• Gastrointestinal hemorrhage
• Hallucinations
• Hyperventilation
• Injection site reaction
• Malaise
• Mucositis
• Petechia
• Rash
• Renal function abnormalities
• Respiratory acidosis
• Respiratory failure
• Seizure
• Stomatitis

Please Note

There are some situations where AmBisome may not be not be a suitable treatment. Be sure to advise your doctor if:

• your are taking any azole antifungals (ketoconazole, itraconazole, fluconazole, etc.)
• you are pregnant, trying to become pregnant, or breastfeeding
• have had any problems with your kidneys